Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice
| Autor: | G G Steel, S L Kauffman, A.Y. Rostom |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Cancer Research Misonidazole Pathology medicine.medical_specialty Radiosensitizer Neoplasms Radiation-Induced Intestinal Neoplasm Rectum Cecal Neoplasms Adenocarcinoma chemistry.chemical_compound Mice Intestinal Neoplasms medicine Neoplasm Animals business.industry Rectal Neoplasms Incidence (epidemiology) medicine.disease Mice Inbred C57BL medicine.anatomical_structure Oncology chemistry Nitroimidazoles Abdomen business Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradiation the proportion of mice developing tumours was higher, but the difference was not statistically significant. However, there was a significant increase in the incidence of multiple tumours, largely attributable to tumours arising in the rectum. Images Fig. 1 Fig. 2 Fig. 3 |
| Databáze: | OpenAIRE |
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