Interference phase-contrast imaging technology without beam separation
| Autor: | Seiji Nishiwaki, Tsuguhiro Korenaga, Kenji Narumi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Physics Multidisciplinary Microscope business.industry lcsh:R Phase-contrast imaging lcsh:Medicine Grating Interference (wave propagation) Article law.invention 03 medical and health sciences Wavelength 030104 developmental biology 0302 clinical medicine Optics law Astronomical interferometer lcsh:Q lcsh:Science business Refractive index 030217 neurology & neurosurgery Beam (structure) |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-38359-9 |
| Popis: | Interferometers are widely used in science and industry to measure small displacements, changes in refractive index, and surface irregularities. In all interferometers, including phase-contrast microscopes and DICs (differential interference contrast microscopes), light from a single source is split into two beams that travel along different optical paths. They are then recombined to produce interference. The fundamental operation of beam separation makes device configuration more complex and adds to the bulk of the equipment. In this study we propose a new method of observing phase-contrast images without beam separation by using self-interference inside a grating coupler structure disposed on the observation plane. We experimentally demonstrate that the self-interference principle can generate phase-contrast images using a simple configuration. From measurements using a multilevel phase plate, we confirm its phase-contrast depth resolution to approach one- tenth of a wavelength. |
| Databáze: | OpenAIRE |
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