Heart Rate Variability with Deep Breathing in Drug-Naïve Patients with Schizophrenia

Autor:	Ying Chun Tai, I. Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Po See Chen, Yen Kuang Yang, Lan Ting Lee, Shih Hsien Lin, Hsin Chun Tsai
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Supine position Blood Pressure Autonomic Nervous System behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Heart Rate Parasympathetic Nervous System Internal medicine mental disorders Heart rate medicine Humans Heart rate variability 0501 psychology and cognitive sciences Applied Psychology business.industry Respiration 05 social sciences medicine.disease Autonomic nervous system Drug-naïve Neuropsychology and Physiological Psychology Blood pressure Schizophrenia Cardiology Reflex Female business 030217 neurology & neurosurgery medicine.drug
Zdroj:	Applied Psychophysiology and Biofeedback. 45:275-282
ISSN:	1573-3270 1090-0586
DOI:	10.1007/s10484-020-09489-6
Popis:	Abnormal autonomic nervous system (ANS) function may result in poor outcomes in patients with schizophrenia. Altered cardio-respiratory coupling, which indicates suppression of vagal activity, was identified as an important trait in patients with schizophrenia and their unaffected relatives. Heart rate variability (HRV) in standardized bedside reflex tests has been studied, mostly in medicated patients with schizophrenia whose ANS function could be influenced by medication. Our study aimed to explore the autonomic function differences between drug-naïve patients with schizophrenia and healthy individuals during challenge tests combining respiration and HRV analysis. Forty-two drug-naïve patients with schizophrenia were matched with 42 healthy controls in terms of age and gender. Their beat-to-beat blood pressure and heart rate were monitored in the supine position as a survey of ANS function, and the mean heart rate range (MHRR) was measured under deep-breathing challenge. A decreased MHRR, a sensitive sign indicating an impaired parasympathetic response, during the deep-breathing challenge among the drug-naïve patients with schizophrenia was found. Drug-naïve patients with schizophrenia may have a parasympathetic dysfunction in the early stages of schizophrenia before medication is introduced, which could be considered a neurobiological marker in the pathophysiology of schizophrenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f081cf9656d41678844f716cfa05e44f https://doi.org/10.1007/s10484-020-09489-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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