Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma
| Autor: | A G de Coca, M. J. Terol, Norma C. Gutiérrez, Alexander Schmitz, Anna Sureda, Martin Schmidt-Hieber, F de Arriba, Bruno Paiva, A. Orfao, N. de las Heras, Juan F. Blanco, Y. González, M.V. Mateos, Miguel-Teodoro Hernández, Lucía López-Corral, M B Vidriales, Julia Almeida, Jesús F. San-Miguel, Albert Oriol, J.J. Lahuerta, Alejandro Martín, J de la Rubia, Hans Erik Johnsen, Martin Perez-Andres, J. Bladé |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male malignant transformation Cancer Research Pathology medicine.medical_specialty Stromal cell Plasma Cells Paraproteinemias CD34 Bone Marrow Cells Enzyme-Linked Immunosorbent Assay Biology plasma cells Immunophenotyping Cell Movement hemic and lymphatic diseases medicine Humans Prospective Studies Cells Cultured Multiple myeloma Aged Aged 80 and over B-Lymphocytes monoclonal gammopathies bone marrow niche competition Hematology Middle Aged Flow Cytometry Hematopoietic Stem Cells medicine.disease Clone Cells Haematopoiesis Leukemia medicine.anatomical_structure Oncology Case-Control Studies Cancer research Female Bone marrow Multiple Myeloma Monoclonal gammopathy of undetermined significance |
| Zdroj: | LEUKEMIA r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Digital.CSIC. Repositorio Institucional del CSIC Paiva, B, Pérez-Andrés, M, Vídriales, M-B, Almeida, J, de Las Heras, N, Mateos, M-V, López-Corral, L, Gutiérrez, N C, Blanco, J, Oriol, A, Hernández, M T, de Arriba, F, de Coca, A G, Terol, M-J, de la Rubia, J, González, Y, Martín, A, Sureda, A, Schmidt-Hieber, M, Schmitz, A, Johnsen, H E, Lahuerta, J-J, Bladé, J, San-Miguel, J F & Orfao, A 2011, ' Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma ', Leukemia, vol. 25, no. 4, pp. 697-706 . https://doi.org/10.1038/leu.2010.320 BASE-Bielefeld Academic Search Engine |
| ISSN: | 1476-5551 0887-6924 |
| Popis: | Disappearance of normal bone marrow (BM) plasma cells (PC) predicts malignant transformation of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) into symptomatic multiple myeloma (MM). The homing, behavior and survival of normal PC, but also CD34 hematopoietic stem cells (HSC), B-cell precursors, and clonal PC largely depends on their interaction with stromal cell-derived factor-1 (SDF-1) expressing, potentially overlapping BM stromal cell niches. Here, we investigate the distribution, phenotypic characteristics and competitive migration capacity of these cell populations in patients with MGUS, SMM and MM vs healthy adults (HA) aged 60 years. Our results show that BM and peripheral blood (PB) clonal PC progressively increase from MGUS to MM, the latter showing a slightly more immature immunophenotype. Of note, such increased number of clonal PC is associated with progressive depletion of normal PC, B-cell precursors and CD34 HSC in the BM, also with a parallel increase in PB. In an ex vivo model, normal PC, B-cell precursors and CD34 HSC from MGUS and SMM, but not MM patients, were able to abrogate the migration of clonal PC into serial concentrations of SDF-1. Overall, our results show that progressive competition and replacement of normal BM cells by clonal PC is associated with more advanced disease in patients with MGUS, SMM and MM. © 2011 Macmillan Publishers Limited All rights reserved. |
| Databáze: | OpenAIRE |
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