Chronic Oral Toxicity Studies of Triacetyl Diphenyl Isatin in Dogs and Rats*

Autor:	Robert Pfaff, Siegfried Woislawski, Lyman C. Boynton, Elliott A. Maynard, Harold C. Hodge
Rok vydání:	1953
Předmět:	Isatin Indoles business.industry medicine.medical_treatment Biphenyl Compounds Laxative Pharmacology Rats Biphenyl compound chemistry.chemical_compound Dogs chemistry Animals Medicine Oral toxicity In degree business Chronic toxicity Antipsychotic Agents
Zdroj:	Journal of the American Pharmaceutical Association (Scientific ed.). 42:468-470
ISSN:	0095-9553
DOI:	10.1002/jps.3030420805
Popis:	The results of acute and chronic toxicity studies of Triacetyl diphenyl isatin (TDI) on rats and on dogs are reorted. The data obtained indicate TDI is only slightly toxic and cannot be classizd as a high-grade irritant. In preliminary tests, human adult subjects showed increasing laxative effects with increasing doses. Relatively few undesirable side effects were reported, and those were moderate or slight in degree.
Databáze:	OpenAIRE
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