Understanding of the Molecular Mechanisms of Allergy

Autor:	Meinir Jones
Rok vydání:	2019
Předmět:	0301 basic medicine Allergy Th2 response business.industry Disease medicine.disease Early life 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Hygiene hypothesis Immunology Medicine business 030217 neurology & neurosurgery
Zdroj:	Methods in Molecular Biology ISBN: 9781493995899 Allergy Methods and Protocols ISBN: 9780896038967
DOI:	10.1007/978-1-4939-9591-2_1
Popis:	The prevalence of allergic disease has dramatically increased over the past 30 years in Westernised countries. It is unlikely that the rapid increase in the prevalence of allergic disease is the result of genetic changes, which highlights the importance of environmental factors in the development of allergic disease. The 'hygiene hypothesis' was put forward in 1989 and focused attention on the notion that exposure to microbes and their products in early life can modify the risk for development of allergic disease. Infections were thought to polarize the immunological response towards a Th2-mediated immune responses causing allergic disease. However it is likely that the Th1/Th2 imbalance is too simplistic to explain the increased prevalence of allergic disease. Current research is focusing on understanding the role of T regulatory cells in inducing a state of tolerance and the resulting modified Th2 response observed in natural and induced tolerance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07fbba07a603bc107ceee25a0cef5a2 https://doi.org/10.1007/978-1-4939-9591-2_1 Zobrazit plný text záznamu