Regulation of neuronal cdc20 (p55cdc) expression by the plasticity-related transcription factor zif268
| Autor: | Ann-Marie Conway, Allan James, Jie Zang, Brian J. Morris |
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| Rok vydání: | 2007 |
| Předmět: |
Cdc20 Proteins
EGR1 Down-Regulation Cell Cycle Proteins Hippocampal formation Biology Hippocampus PC12 Cells Anaphase-Promoting Complex-Cyclosome Mice Cellular and Molecular Neuroscience Neuroplasticity medicine Animals Cells Cultured Early Growth Response Protein 1 Cerebral Cortex Mice Knockout Neurons Regulation of gene expression Neuronal Plasticity Ubiquitin-Protein Ligase Complexes Transfection Molecular biology Rats Up-Regulation medicine.anatomical_structure Gene Expression Regulation Cerebral cortex Synaptic plasticity NMDA receptor |
| Zdroj: | Synapse. 61:463-468 |
| ISSN: | 1098-2396 0887-4476 |
| Popis: | Most forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down-regulation of cdc20 (p55(cdc))--a regulatory protein for the anaphase-promoting complex, which controls access of specific substrates to the proteasome--was observed after transfection of a neuronal cell line with zif268. Treatment of cultured hippocampal neurones with NMDA, which elevates endogenous zif268 levels, also decreased cdc20 levels. Conversely, the levels of cdc20 were found to be increased in the cerebral cortex of mice with targeted deletion of the zif268 gene, when compared with wild-type controls. Our findings indicate that expression of the cdc20 gene is down-regulated by zif268 in neuronal cells, and provide new evidence that altered expression of proteasome-regulatory genes following zif268 induction may be a key component of long-lasting CNS plasticity. |
| Databáze: | OpenAIRE |
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