Increased tumor growth after high pressure pneumoperitoneum with helium and air
| Autor: | H. Jaap Bonjer, Amir Mearadji, Philippe Wittich, Richard L. Marquet |
|---|---|
| Přispěvatelé: | Surgery |
| Rok vydání: | 2004 |
| Předmět: |
Laparoscopic surgery
Insufflation medicine.medical_specialty genetic structures medicine.medical_treatment chemistry.chemical_element Helium Neoplasm Seeding Pneumoperitoneum medicine Animals Tumor growth Carbon dioxide insufflation Peritoneal Neoplasms business.industry Air Rats Inbred Strains respiratory system medicine.disease Surgery Rats chemistry High pressure Anesthesia business Pneumoperitoneum Artificial |
| Zdroj: | Journal of Laparoendoscopic & Advanced Surgical Techniques-Part A, 4, 205-208. Mary Ann Liebert Inc. |
| ISSN: | 1092-6429 |
| Popis: | Tumor growth appears proportional to the pressure of carbon dioxide insufflation during laparoscopic surgery. Air and helium are alternative insufflation gases. The objective of this study is to assess tumor growth after air and helium insufflation at different pressures.Ninety-six WAG rats were allocated to either air or helium. In both arms, rats were randomly exposed to a one hour gasless procedure, or to 4 mm Hg, 10 mm Hg, or 16 mm Hg insufflation. At the start of the procedure, 500,000 CC531 tumor cells were injected intraperitoneally. After three weeks, intraperitoneal tumor growth was assessed.Higher insufflation pressures were associated with greater tumor growth. No difference of tumor growth between air and helium insufflation was found.In this experimental model, insufflation pressure appeared to have a greater impact on tumor growth than the type of gas. Further studies are necessary but it seems prudent to recommend employment of lower insufflation pressures in laparoscopic oncologic surgery. |
| Databáze: | OpenAIRE |
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