Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia
| Autor: | A. Maksimow, E. Salmi, Arvi Yli-Hankala, Mika Sarkela, Satu K. Jääskeläinen, Susanna Hinkka-Yli-Salomäki, Kaike K. Kaisti, Jaakko Långsjö, Harry Scheinin |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Electroencephalography Clinical neurophysiology Sensitivity and Specificity Physiology (medical) Monitoring Intraoperative medicine Humans Ketamine Entropy (energy dispersal) Propofol Anesthetics Dissociative medicine.diagnostic_test Electromyography Spectral entropy Unconsciousness Brain Sensory Systems Neurology Anesthesia Anesthetic Neurology (clinical) medicine.symptom Psychology Anesthetics Intravenous medicine.drug |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 117(8) |
| ISSN: | 1388-2457 |
| Popis: | Objective: To study the effects of S-ketamine on the EEG and to investigate whether spectral entropy of the EEG can be used to assess the depth of hypnosis during S-ketamine anesthesia. Methods: The effects of sub-anesthetic (159 (21); mean (SD) ng/ml) and anesthetic (1959 (442) ng/ml) serum concentrations of S-ketamine on state entropy (SE), response entropy (RE) and classical EEG spectral power variables (recorded using the Entropye Module, GE Healthcare, Helsinki, Finland) were studied in 8 healthy males. These EEG data were compared with EEG recordings from 6 matching subjects anesthetized with propofol. Results: The entropy values decreased from the baseline SE 85 (3) and RE 96 (3) to SE 55 (18) and RE 72 (17) during S-ketamine anesthesia but both inter- and intra-individual variation of entropy indices was wide and their specificity to indicate unconsciousness was poor. Propofol induced more pronounced increase in delta power (P!0.02) than S-ketamine, whereas anesthetic S-ketamine induced more high frequency EEG activity in the gamma band (P!0.001). Relative power of 20–70 Hz EEG activity was associated with high SE (PZ0.02) and RE (PZ0.03) values during S-ketamine anesthesia. Conclusions: These differences in low and high frequency EEG power bands probably explain why entropy monitor, while adequate for propofol, is not suitable for assessing the depth of S-ketamine anesthesia. Significance: The entropy monitor is not adequate for monitoring S-ketamine-induced hypnosis. q 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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