2-[18F]Fluoroethyl tosylate – a versatile tool for building18F-based radiotracers for positron emission tomography
| Autor: | Torsten Kniess, Jörg Steinbach, Markus Laube, Peter Brust |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
medicine.diagnostic_test Chemistry Pet chemistry Organic Chemistry Pharmaceutical Science Biochemistry Combinatorial chemistry Fluoroethyl tosylate Positron emission tomography TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY Drug Discovery medicine Molecular Medicine Reactivity (chemistry) Preclinical imaging Nuclear chemistry |
| Zdroj: | MedChemComm 6(2015), 1714-1754 |
| ISSN: | 2040-2511 2040-2503 |
| DOI: | 10.1039/c5md00303b |
| Popis: | Positron emission tomography (PET) is a modern in vivo imaging technique and an important diagnostic modality for clinical and pre-clinical research. The incorporation of a radionuclide like fluorine-18 into a target molecule to form PET radiopharmaceuticals is a repeated challenge for radiochemists. 18F-Fluoroethylation is a well acknowledged method for 18F-radiolabeling and 2-[ 18F]fluoroethyltosylate ([ 18 F]FEts) is a preferred reagent because of its high reactivity to phenolic, thiophenolic, carboxylic and amide functions. The review will highlight the role of [ 18F]FEts in PET-chemistry, and summarize its applicability in radiotracer design. The radiolabeling conditions and pros and cons of direct and indirect radiolabeling as well the aspects of reactivity of [ 18F]FEts compared with other [ 18F]fluoroalkylating reagents will be discussed comprehensively. |
| Databáze: | OpenAIRE |
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