Neurocognitive functioning in HIV-1 infection: effects of cerebrovascular risk factors and age
Autor: | Jessica M. Foley, Melissa Choi, Mark L. Ettenhofer, April D. Thames, Iraj Siddiqi, Karen I. Mason, Charles H. Hinkin, Matthew Wright, Steven A. Castellon |
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Rok vydání: | 2010 |
Předmět: |
Senescence
Adult Male medicine.medical_specialty HIV Infections Severity of Illness Index Article Developmental psychology Central nervous system disease Arts and Humanities (miscellaneous) Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine Severity of illness Developmental and Educational Psychology medicine Verbal fluency test Humans Risk factor Age Factors Brain Cognition Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Cerebrovascular Disorders Neuropsychology and Physiological Psychology HIV-1 Female Psychology Cognition Disorders Neurocognitive |
Zdroj: | The Clinical neuropsychologist. 24(2) |
ISSN: | 1744-4144 |
Popis: | This study examined the interactive effects of cerebrovascular risks, advancing age, and HIV infection on neurocognition, and explored whether pharmacological treatment of cerebrovascular risk factors attenuated neurocognitive dysfunction. Participants included 98 HIV-seropositive adults (cerebrovascular risk: 23.5%; age >50: 27.6%). Cerebrovascular risk was associated with slower processing speed even after controlling for age effects (b = −2.071; p = .04), and the interaction of age and cerebrovascular risk was associated with poorer verbal fluency (b = 1.276, p = .002). Participants with pharmacologically untreated cerebrovascular risk demonstrated reduced processing speed, learning/memory, and executive functioning relative to those on medication. Poor cerebrovascular health confers significant risk for HIV+ individuals, and this effect may be of greater consequence than advancing age. The cognitive impact of risk appears to be more pronounced in the absence of adequate pharmacological treatment. |
Databáze: | OpenAIRE |
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