Health-related quality-of-life study in patients with carcinoma of the thyroid after thyroxine withdrawal for whole body scanning
| Autor: | Kwok-Hung Au, Hoi‐Leung Leung, Siu-Hong Lee, Sin-Ming Chow, Tim‐Shing Choy, Angus Leung, Stephen C.K. Law, Nga‐Yan Yeung, Alex K.C. Leung, Chi‐Chung Shek |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Emotions Thyrotropin Thyroid carcinoma Iodine Radioisotopes Quality of life Asian People Hypothyroidism Internal medicine Surveys and Questionnaires Carcinoma Medicine Humans In patient Prospective Studies Thyroid Neoplasms Aged business.industry Thyroid Cancer Middle Aged medicine.disease Carcinoma Papillary Surgery Thyroxine medicine.anatomical_structure Otorhinolaryngology Quality of Life Hong Kong Female business Whole body Hormone |
| Zdroj: | The Laryngoscope. 116(11) |
| ISSN: | 0023-852X |
| Popis: | The authors studied the change of health-related quality of life (HR-QOL) in patients with differentiated thyroid carcinoma (DTC) with thyroxine (T4) withdrawal in preparation for whole body radioactive iodine scanning.Seventy-eight patients with DTC and history of radioactive iodine (RAI) ablation were prospectively recruited. They completed the Functional Assessment of Cancer Treatment-General (FACT-G) questionnaire on weeks 0, 2, and 4 after T4 withdrawal with corresponding checking of serum thyroid-stimulating hormone (TSH).Overall, 74.5% (58 of 78) of patients completed all FACT-G. Comparing FACT-G scores at weeks 0 and 4, "physical" (P.001), "social" (P = .04), and "emotional" (P = .047) aspects were lowered as well as "total" HR-QOL (P = .001). However, the "functional" domain of HR-QOL was not affected (P = .14). Comparing FACT-G scores at week 0 and 2, we found that "physical" (P = .049) and "total" (P = .05) HR-QOL were affected early (in the first 2 weeks) in T4 withdrawal. Comparison of week 2 and 4 showed that in the later half of the withdrawal period, "physical" (P = .001), "emotional" (P = .02), and "total" FACT-G scores (P = .002) were affected. Mean TSH level (in mIU/L) increased gradually: 2.8 (week 0), 42.8 (week 2), 97 (week 3), and 153 (week 4). The percentage of patients attaining TSH level of30 mIU/L were 55% (week 2), 96.2% (week 3), and 100% (week 4).HR-QOL declines with time of T4 withdrawal. The impact is more severe in the later period of T4 withdrawal. In 3 weeks, 96.2% of our patients attained TSH level of 30 mIU/L. To minimize the impact on HR-QOL, duration of T4 withdrawal can be decreased to 3 weeks. |
| Databáze: | OpenAIRE |
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