Molecular Pathogenesis of Psoriasis and Biomarkers Reflecting Disease Activity
| Autor: | Hiroyoshi Nozaki, Masaru Honma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemokine Antimicrobial peptides Adipokine Review Disease Bioinformatics 030207 dermatology & venereal diseases 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Psoriasis Medicine fatty acid-binding protein Th17 cells adipokines glycoproteins biology business.industry Interleukin General Medicine medicine.disease inflammatory skin disease 030104 developmental biology biology.protein Biomarker (medicine) business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 3199, p 3199 (2021) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Psoriasis is a chronic inflammatory skin disease induced by multifactorial causes and is characterized by bothersome, scaly reddish plaques, especially on frequently chafed body parts, such as extensor sites of the extremities. The latest advances in molecular-targeted therapies using biologics or small-molecule inhibitors help to sufficiently treat even the most severe psoriatic symptoms and the extra cutaneous comorbidities of psoriatic arthritis. The excellent clinical effects of these therapies provide a deeper understanding of the impaired quality of life caused by this disease and the detailed molecular mechanism in which the interleukin (IL)-23/IL-17 axis plays an essential role. To establish standardized therapeutic strategies, biomarkers that define deep remission are indispensable. Several molecules, such as cytokines, chemokines, antimicrobial peptides, and proteinase inhibitors, have been recognized as potent biomarker candidates. In particular, blood protein markers that are repeatedly measurable can be extremely useful in daily clinical practice. Herein, we summarize the molecular mechanism of psoriasis, and we describe the functions and induction mechanisms of these biomarker candidates. |
| Databáze: | OpenAIRE |
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