Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression
| Autor: | William A. Haseltine, Joseph Sodroski, Warren J. Leonard, Penny B. Svetlik, Craig A. Rosen, Yuji Wano, Warner C. Greene, Wei Chun Goh, Nancy J. Peffer |
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| Rok vydání: | 1986 |
| Předmět: |
Multidisciplinary
Leukemia Genes Viral Activator (genetics) Nucleic Acid Hybridization Receptors Interleukin-2 Biology Virology Molecular biology Jurkat cells Deltaretrovirus Cell Line Growth factor receptor Gene Expression Regulation Cell surface receptor Interleukin-21 receptor Gene expression Humans Interleukin-2 5-HT5A receptor RNA Messenger Receptors Immunologic Receptor |
| Zdroj: | Science (New York, N.Y.). 232(4752) |
| ISSN: | 0036-8075 |
| Popis: | The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection. |
| Databáze: | OpenAIRE |
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