The expression of the beta 1 integrin CD29 and the beta 2 integrin CD11b is decreased in peripheral blood lymphocytes from Graves' disease patients
| Autor: | Girón Ja, Gavilán I, M. Aguilar, J Rojano, S Sasian, L Escobar |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Thyroid Hormones endocrine system medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Lymphocyte Macrophage-1 Antigen Thyroiditis Endocrinology Antithyroid Agents Internal medicine Immunopathology Humans Medicine Lymphocytes Prospective Studies Autoimmune disease Methimazole biology business.industry Cell adhesion molecule Integrin beta1 Thyroiditis Autoimmune CD29 General Medicine Middle Aged medicine.disease Graves Disease medicine.anatomical_structure Integrin alpha M CD18 Antigens Immunology biology.protein Female business Biomarkers |
| Zdroj: | European Journal of Endocrinology. 139:349-354 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | We have prospectively examined the percentage of peripheral blood lymphocytes which expressed adhesion molecules in untreated Graves' disease patients. Eighteen patients with Graves disease, twenty-four patients with Hashimoto's thyroiditis and thirty-two sex- and age-matched healthy control subjects were studied. The expression of the lymphocyte adhesion molecules beta-1 integrin CD29, beta-2 integrin CD11b and L-selectin Leu8 (CD62L) was analyzed by cytofluorometry. A decreased percentage of CD29+ and CD11b+ lymphocytes was observed in hyperthyroid patients in comparison with Hashimoto's thyroiditis patients and healthy controls. However, there was no difference in the percentage of CD62L+ lymphocytes in the three groups. Percentages of lymphocyte activation markers, hyperthyroid status, presence or absence of ophthalmopathy or serum levels of antithyroid antibodies were not related to the proportions of CD29+ or CD1 1b+ lymphocytes. Four Graves' patients required radical therapy but after the treatment, there was no modification in the percentages of CD29+ and CD1 1b+ lymphocytes compared with those determined at diagnosis. Our findings suggest that the decrease in beta-1 and beta-2 integrins could be a predisposing marker of development of Graves' disease. |
| Databáze: | OpenAIRE |
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