A new xanthyletin-type coumarin from the roots of Peucedanum praeruptorum
| Autor: | Sheng-Li Niu, Chi Gong, Wei Ning, Yuan-Yuan Zu, Xin-Yu Li, Hui-Ming Hua, Ming-Xu Tang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
010405 organic chemistry Cell growth Chemistry Stereochemistry Chemical structure Organic Chemistry Pharmaceutical Science Xanthyletin General Medicine Coumarin 01 natural sciences Human prostate 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Peucedanum praeruptorum Complementary and alternative medicine Drug Discovery Ic50 values Molecular Medicine |
| DOI: | 10.6084/m9.figshare.7564640.v2 |
| Popis: | A new xanthyletin-type coumarin, neopeucedalactone (1), was isolated from the roots of Peucedanum praeruptorum Dunn. Its chemical structure was elucidated based on extensive spectroscopic interpretation. The absolute configurations of xanthyletin-type coumarin were determined by comparing experimental and calculated ECD spectra for the first time. Compound 1 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60, THP-1 cell lines, and human prostate cancer PC-3 cell lines, with IC50 values of 9.97, 27.80, and 48.68 µM, respectively. |
| Databáze: | OpenAIRE |
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