Outbreak of Mycobacterium tuberculosis Beijing Strain in a High School in Yunnan, China
| Autor: | Xing Yang, Yu Pang, Lin Xu, Rui Yang, Huijuan Yang, Lianyong Chen, Tao Chen, Jinglong Hou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
China Tuberculosis Adolescent education 030231 tropical medicine Disease Outbreaks Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Beijing Virology Humans Medicine Tuberculosis Pulmonary Genotyping Index case Schools biology business.industry Transmission (medicine) Outbreak Articles medicine.disease biology.organism_classification Infectious Diseases Female Parasitology business Demography |
| Zdroj: | Am J Trop Med Hyg |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.19-0533 |
| Popis: | In this study, we report an investigation of a tuberculosis (TB) outbreak in a high school in China. Eleven students with active TB were identified. A culture-negative 17-year-old girl was considered as index case affected by pulmonary and meningeal TB. Screening results indicated latent TB in 32.8% of the students in the classroom of index case, whereas a significantly decreased prevalence of TB infection was found among students on the same floor, ranging from 1.3 to 8.2%. Genotyping revealed that all the Mycobacterium tuberculosis (MTB) isolates belonged to Beijing spoligotype international types 1 (SIT1). In conclusion, a diagnostic delay for the culture-negative index case played an important role in the transmission of Beijing genotype MTB strain in the boarding school in Yunnan. The separate locations of classrooms and sufficient air ventilation contributed to the significant difference in proportions of TB infection between classmates and other students in this outbreak. |
| Databáze: | OpenAIRE |
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