Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster
| Autor: | Zhi-Yong Chu, J. Luan, X. Feng, Y.-X. Zou, S. Chen, M.-H. Ruan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Aging Antioxidant medicine.medical_treatment Riboflavin SOD1 Longevity SOD2 Medicine (miscellaneous) medicine.disease_cause Antioxidants Lipofuscin Superoxide dismutase Andrology 03 medical and health sciences 0302 clinical medicine Superoxide Dismutase-1 Medicine Animals Humans Nutrition and Dietetics biology business.industry Superoxide Dismutase fungi food and beverages Hydrogen Peroxide biology.organism_classification Catalase Oxidative Stress 030104 developmental biology Drosophila melanogaster Dietary Supplements biology.protein Female Geriatrics and Gerontology business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | The journal of nutrition, healthaging. 21(3) |
| ISSN: | 1760-4788 |
| Popis: | This study investigated the effect of riboflavin on aging in Drosophila melanogaster (fruit fly). Experimental study. Naval Medical Research Institute. Fruit fly Drosophila melanogaster. After lifelong supplement of riboflavin, the lifespan and the reproduction of fruit flies were observed. Hydrogen peroxide (H2O2) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded. The activity of copper-zinc-containing superoxide dismutase (SOD1), manganese containing SOD (SOD2) and catalase (CAT) and lipofuscin (LF) content were determined. Riboflavin significantly prolonged the lifespan (Log rank χ2=16.677, P |
| Databáze: | OpenAIRE |
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