Pharmacokinetics of cetamolol in hypertensive patients with normal and compromised renal function
| Autor: | C. A. Carter, D. K. H. Lee, S. A. Acchiardo, V. A. Skoutakis, M. Kraml, M. A. Klausner, C. G. Ingebretsen |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Adrenergic beta-Antagonists Urology Cmax Renal function Blood Pressure Kidney Function Tests chemistry.chemical_compound Sex Factors Pharmacokinetics Heart Rate Internal medicine Heart rate Acetamides medicine Humans Pharmacology (medical) Aged Pharmacology business.industry Antagonist Middle Aged Cetamolol Diet Endocrinology Blood pressure chemistry Creatinine Hypertension Female Kidney Diseases Hemodialysis business |
| Zdroj: | Journal of clinical pharmacology. 28(5) |
| ISSN: | 0091-2700 |
| Popis: | The efficacy, safety, and pharmacokinetic parameters of a 30-mg oral dose of cetamolol hydrochloride (Betacor), a new synthetic cardioselective beta-adrenoceptor antagonist, with intrinsic sympathomimetic activity, were evaluated by studying 32 hypertensive patients with normal renal function or different degrees of renal impairment. After administration of cetamolol, serial blood and urine sample collections, as well as vital sign determinations for the next 48 hours, were performed in all patients (with the exception of urine collection, which was not possible in hemodialysis patients). Results indicate that cetamolol's pharmacokinetic parameters are significantly changed in patients who have moderate or severe renal impairment. Specifically, as the severity of renal impairment increased, the maximum serum concentration (Cmax) and the area under the serum concentration-time curve (AUC) increased, whereas the renal clearance (CLR), urinary excretion, and total body clearance (CL) decreased. Additionally, significant direct or inverse correlations for AUC, CL, CLR, and urinary excretion with creatinine clearance (CLCR) were demonstrated. In the subjects with mild renal impairment, the trends toward changes in the cetamolol pharmacokinetic parameters were evident, though small and not statistically significant. Although anuric, patients on hemodialysis still retained the ability metabolically to clear cetamolol at a rate of about one-third of that found in normal subjects. Reductions in blood pressure and heart rate also were found to be greater and more prolonged as the severity of renal impairment increased. There were no adverse drug or toxic effects noted in any of the study patients. Based on these findings, dosing recommendations are suggested for patients who have compromised renal function because of the effects of renal function on the pharmacokinetics of cetamolol. |
| Databáze: | OpenAIRE |
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