Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes
Autor: | P. Collinet, Christine Decanter, Audrey Uk, Hélène Behal, Camille Robin, Anne-Laure Barbotin, Chrystèle Rubod, Geoffroy Robin |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oocyte morphology
Male QH471-489 Pregnancy Rate medicine.medical_treatment Endometriosis Intracytoplasmic sperm injection Cohort Studies Endocrinology Oogenesis Pregnancy In vitro fertilization Ovarian Diseases Birth Rate Reproduction Obstetrics and Gynecology Prognosis medicine.anatomical_structure Treatment Outcome Cohort Female France Infertility Female Infertility Adult medicine.medical_specialty Fertilization in Vitro Oocyte quality medicine Humans Endometrioma Sperm Injections Intracytoplasmic Cell Size Retrospective Studies Gynecology In vitro fertilisation business.industry Research Infant Newborn Retrospective cohort study Gynecology and obstetrics medicine.disease Oocyte Sperm Reproductive Medicine RG1-991 Oocytes business Developmental Biology |
Zdroj: | Reproductive Biology and Endocrinology : RB&E Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-12 (2021) |
ISSN: | 1477-7827 |
Popis: | Background Infertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for in vitro fertilization (IVF) outcomes. According to some authors, the morphology of oocytes could also be a non-invasive marker of oocyte quality. The aim of this study was to evaluate the relationship between endometriosis and oocyte morphology after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI) on a large oocyte cohort. Methods Single-center comparative retrospective study in the academic In Vitro Fertilization (IVF) unit of the Lille University Hospital. A total of 596 women treated for IVF-ICSI with ejaculated spermatozoa for sperm alterations were included. They were classified as endometriosis (n = 175) or control groups (n = 401). The morphological evaluation of 2,016 mature oocytes from 348 cycles of patients with endometriosis was compared with that of 4,073 mature oocytes from 576 control cycles. The main outcome measures were Average Oocyte Quality Index (AOQI) and metaphase II oocyte morphological scoring system (MOMS). Comparison of groups was carried out by a mixed linear model and by a generalized estimation equation model with a "patient" random effect to consider that a patient might have several attempts. Results No difference in AOQI and MOMS scores was found between endometriosis and control women (adjusted p = 0.084 and 0.053, respectively). In case of endometriosis, there were significantly fewer metaphase II oocytes retrieved, embryos obtained, grade 1 embryos and number of cumulative clinical pregnancies compared to controls. In the endometriosis group, endometriosis surgery was associated with a reduced number of mature oocytes retrieved, and the presence of endometrioma(s) was associated with some abnormal oocyte shapes. Nevertheless, no difference concerning the AOQI and MOMS scores was found in these subgroups. Conclusion Endometriosis does not have a negative impact on oocytes’ morphology in IVF-ICSI. Trial registration On December 16, 2019, the Institutional Review Board of the Lille University Hospital gave unrestricted approval for the anonymous use of all patients’ clinical, hormonal and ultrasound records (reference DEC20150715-0002). |
Databáze: | OpenAIRE |
Externí odkaz: |