Temporal trends of organochlorine concentrations in umbilical cord blood of newborns from the lower north shore of the St. Lawrence river (Québec, Canada)
| Autor: | Pierre Ayotte, Claire Laliberté, Eric Dewailly, Gina Muckle, Frederic Dallaire |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Rural Population Insecticides Health Toxicology and Mutagenesis Population Biology Umbilical cord chemistry.chemical_compound Animal science Pregnancy Environmental protection medicine Animals Humans education education.field_of_study Fishes Infant Newborn Quebec Public Health Environmental and Occupational Health Environmental Exposure Hexachlorobenzene Environmental exposure Pesticide Fetal Blood medicine.disease Fish consumption Polychlorinated Biphenyls Diet medicine.anatomical_structure Seafood chemistry Maternal Exposure Cord blood Indians North American Environmental Pollutants Female Research Article |
| Zdroj: | Europe PubMed Central Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | This study describes the time trends of organochlorines [OCs; 14 polychlorinated biphenyls (PCBs) and 11 chlorinated pesticides] in umbilical cord plasma of newborns in a remote Canadian coastal population. We analyzed 408 cord blood samples collected between 1993 and 2000 for PCBs, chlordanes, dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyltrichloroethylene (DDE), hexachlorobenzene (HCB), and n-3 fatty acids. We also gathered information on the mothers (age, past and present residence, ethnic group, use of tobacco during pregnancy, and breast-feeding during previous pregnancies). From 1993 to 2000, mean concentrations of PCBs, chlordanes, DDT/DDE, and HCB in cord blood decreased by 63%, 25%, 66%, and 69%, respectively (p < 0.0001). Multiple regression analysis with the year of birth as the main independent variable yielded a strong significant exponential decrease for all contaminants (in all age and ethnic groups). We detected no monthly or seasonal pattern. We used n-3 fatty acids concentration as a surrogate of maternal fish consumption. Fish consumption declined only slightly between 1993 and 2000, but this decrease did not contribute significantly to the reduction of OCs. These results show that prenatal exposure to persistent OCs has declined significantly between 1993 and 2000 in this population. |
| Databáze: | OpenAIRE |
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