Deficits in NaCl ingestion after damage to the central nucleus of the amygdala in the rat
| Autor: | Alan N. Epstein, Olivier Galaverna, Shu-Zhen Yao, Laurival A. De Luca, Jay Schulkin |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Sucrose medicine.medical_specialty media_common.quotation_subject Sodium chemistry.chemical_element Amygdala Internal medicine medicine Animals Ingestion Salt intake Desoxycorticosterone media_common Chemistry Angiotensin II General Neuroscience Central nucleus of the amygdala Rats Inbred Strains Sodium Dietary Appetite medicine.disease Rats medicine.anatomical_structure Endocrinology Hematocrit Taste Ingestive behaviors |
| Zdroj: | Brain Research Bulletin. 28:89-98 |
| ISSN: | 0361-9230 |
| Popis: | These studies examined the NaCl intake behaviors of rats with bilateral electrolytic lesions of the central nucleus of the amygdala (CeAX). Daily need-free intake of 3% NaCl was abolished by CeAX even in rats in which it had been enhanced preoperatively by a history of repeated sodium depletions but was slightly restored by three successive postoperative sodium depletions. CeAX rats drank water but not 3% NaCl to high doses of DOCA and to the activation of cerebral angiotensin II, and expressed small but reliable salt intake (need-induced salt intake or salt appetite) after postoperative sodium depletions. Other ingestive behaviors (water drinking, intake of food and 5% sucrose) were normal. When given decreasing concentrations of NaCl solution the CeAX rats rejected them until the concentration reached 0.2%. These findings suggest that lesions to the central nucleus of the amygdala produce a global impairment in salt intake behaviors that is possibly due to an alteration in the central processing of the salt taste signal. |
| Databáze: | OpenAIRE |
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