Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women
| Autor: | Andrew P. Goldberg, Dora M. Berman, Barbara J. Nicklas, Ellen M. Rogus, Karen E. Dennis |
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| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Blood lipids Adipose tissue Fatty Acids Nonesterified Biology Weight Gain chemistry.chemical_compound Weight loss Physiology (medical) Internal medicine Abdomen Weight Loss Adipocytes medicine Humans Aged Glucose tolerance test Lipoprotein lipase medicine.diagnostic_test Cholesterol Lipid metabolism Fasting Glucose Tolerance Test Middle Aged Lipids Lipoprotein Lipase Endocrinology Adipose Tissue chemistry Body Composition Body Constitution Female lipids (amino acids peptides and proteins) medicine.symptom Weight gain |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 279:E1012-E1019 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | This study determines whether changes in abdominal (ABD) and gluteal (GLT) adipose tissue lipoprotein lipase (LPL) activity in response to a 6-mo weight loss intervention, comprised of a hypocaloric diet and low-intensity walking, affect changes in body composition, fat distribution, lipid metabolism, and the magnitude of weight regain in 36 obese postmenopausal women. Average adipose tissue LPL activity did not change with an average 5.6-kg weight loss, but changes in LPL activity were inversely related to baseline LPL activity (ABD: r= −0.60, GLT: r = −0.48; P < 0.01). The loss of abdominal body fat and decreases in total and low-density lipoprotein cholesterol were greater in women whose adipose tissue LPL activity decreased with weight loss despite a similar loss of total body weight and fat mass. Moreover, weight regain after a 6-mo follow-up was less in women whose adipose tissue LPL activity decreased than in women whose LPL increased (ABD: 0.9 ± 0.5 vs. 2.8 ± 0.6 kg, P < 0.05; GLT: 0.2 ± 0.5 vs. 2.8 ± 0.5 kg, P < 0.01). These results suggest that a reduction in adipose tissue LPL activity with weight loss is associated with improvements in lipid metabolic risk factors with weight loss and with diminished weight regain in postmenopausal women. |
| Databáze: | OpenAIRE |
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