An Intraocular Inflammatory Profile of Rubella Associated Uveitis
| Autor: | Z Fazil, J.C. Ten Berge, Anton W. Langerak, W A Dik, Aniki Rothova |
|---|---|
| Přispěvatelé: | Ophthalmology, Immunology |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Adolescent medicine.medical_treatment Cytokine profile Population Eye Infections Viral Rubella Aqueous Humor Uveitis 03 medical and health sciences Infectious uveitis Young Adult 0302 clinical medicine Immunopathology Ophthalmology medicine Immunology and Allergy Humans education Aged 030203 arthritis & rheumatology Aged 80 and over Inflammation education.field_of_study business.industry Middle Aged medicine.disease Flow Cytometry eye diseases Cytokine Intraocular fluid DNA Viral 030221 ophthalmology & optometry Cytokines Female business Rubella virus |
| Zdroj: | Ocular Immunology and Inflammation, 27(3), 418-423. Taylor & Francis Ltd |
| ISSN: | 1744-5078 0927-3948 |
| Popis: | Purpose: To analyze intraocular cytokine levels and cell profiles in patients with rubella virus-associated uveitis (RVU). Methods: We collected intraocular fluid samples from patients with RVU (n = 10), uveitis of other causes (n = 27), and cataract (n = 22). Levels of 15 cytokines (IL-1β, IL-1ra, IL-2, IL-6, IL-6rα, IL-7, IL-8, IL-10, IL-17A, IL-23, TARC, MCP-1, TNF-α, PlGF, and VEGF) were measured using multiplex assay, and intraocular cell populations were determined by multiparameter flowcytometry. Clinical characteristics of RVU patients were collected and compared to laboratory outcomes. Results: RVU patients exhibited high intraocular levels of MCP-1, IL-6rα, and TARC, whilst patients with noninfectious uveitis were characterized by high levels of PlGF. Cataract patients showed high levels of IL-2 and IL-23. Intraocular cell population of RVU patients disclosed mainly T-cells and monocytes/macrophages and B-cells were scarcely detected. Conclusion: RVU patients exhibit a cytokine profile distinct from noninfectious uveitis and cataract. |
| Databáze: | OpenAIRE |
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