Production of influenza pseudotyped lentiviral particles and their use in influenza research and diagnosis: an update
| Autor: | Jimmy C. C. Lai, Jean-Michel Garcia |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Influenzavirus A
Microbiology (medical) Swine viruses Highly pathogenic Transfection medicine.disease_cause Microbiology Birds Viral Proteins Orthomyxoviridae Infections Virology Drug Discovery Influenza Human medicine Animals Humans Molecular Biology Swine Diseases Membrane Glycoproteins biology Bird Diseases Chimera Drug discovery Lentivirus Virion virus diseases Influenza research biology.organism_classification Influenza A virus subtype H5N1 Infectious Diseases Influenza in Birds Plasmids |
| Zdroj: | Expert Review of Anti-infective Therapy. 9:443-455 |
| ISSN: | 1744-8336 1478-7210 |
| Popis: | Pseudotyped viral particles are being used as safe surrogates to mimic the structure and surface of many viruses, including highly pathogenic viruses such as avian influenza H5N1, to investigate biological functions mediated by the envelope proteins derived from these viruses. The first part of this article evaluates and discusses the differences in the production and characterization of influenza pseudoparticles. The second part focuses on the applications that such a flexible tool can provide in modern influenza research, in particular in the fields of drug discovery, molecular biology and diagnosis. |
| Databáze: | OpenAIRE |
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