Intracerebroventricular injection of exendin (5–39) increases food intake of layer-type chicks but not broiler chicks
| Autor: | Tetsuya Tachibana, Atsushi Ohgushi, Ryuichi Ando, Kouichi Sashihara, Kunio Sugahara, Takao Yoshimatsu, Mitsuhiro Furuse |
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| Rok vydání: | 2001 |
| Předmět: |
endocrine system
medicine.medical_specialty Food intake animal structures Intracerebroventricular injection Endogeny Biology Eating Glucagon-Like Peptide 1 Internal medicine medicine Broiler chick Animals Protein Precursors Molecular Biology Injections Intraventricular General Neuroscience digestive oral and skin physiology Antagonist Broiler Glucagon Glucagon-like peptide-1 Peptide Fragments Endocrinology Animals Newborn Gastrointestinal hormone embryonic structures Female Neurology (clinical) Chickens hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Brain Research. 915:234-237 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(01)02943-2 |
| Popis: | To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5–39) on food intake. Intracerebroventricular co-injection of exendin (5–39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5–39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks. |
| Databáze: | OpenAIRE |
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