Analysis of genetic variability at codon 42 within caprine prion protein gene in relation to production traits in Chinese domestic breeds
| Autor: | Xianyong Lan, Hong Chen, Chongyang Wu, Shenrong Hu, Chuanying Pan, Haiyu Zhao, Chuzhao Lei |
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| Rok vydání: | 2011 |
| Předmět: |
China
Genotype Prions Molecular Sequence Data Biology Breeding Polymerase Chain Reaction Quantitative Trait Heritable Gene Frequency Genetic variation Genetics Animals Genetic variability Allele Codon Molecular Biology Allele frequency Genetic association Chi-Square Distribution Base Sequence Goats Body Weight Genetic Variation General Medicine Sequence Analysis DNA Breed Milk Genetic marker Genetic Loci Polymorphism Restriction Fragment Length |
| Zdroj: | Molecular biology reports. 39(4) |
| ISSN: | 1573-4978 |
| Popis: | In this study, genetic variability at codon 42 within prion protein (PRNP) gene and its associations with production traits were investigated in 2002 goats from four Chinese domestic breeds. The frequencies of allele "A" ranged from 0.353 to 0.562 in analyzed goat breeds with Hardy-Weinberg equilibrium (P > 0.05) except Xinong Sannen (XNSN) dairy breed. The establishment of relationships between different genotypes and growth traits was performed in Inner Mongolia white Cashmere (IMWC) breed and revealed an association of the polymorphism with body weight at 7-year-old goats (P = 0.033). The individuals with genotype GG showed heavier body weight than those with genotype AA. Moreover, association analysis detected two significant associations between different genotypes and cashmere yield and fiber length in IMWC breed (P = 0.009, P = 0.048, respectively). In addition, three significant associations of different genotypes with density of milk (a.m. and p.m.), solids-not-fat of milk (P = 0.013, P = 0.009 and P = 0.002), respectively, were found in XNSN breed. Genotype GG had better milk quality than others. These findings suggested that the polymorphism of codon 42 within PRNP was a useful DNA marker for eliminating or selecting excellent individuals in relation to production traits in marker-assist selection breeding of goat. |
| Databáze: | OpenAIRE |
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