Exposure to persistent organic pollutants and sperm sex chromosome ratio in men from the Faroe Islands
| Autor: | Jónrit Halling, Pal Weihe, L. Kvist, Y. Lundberg Giwercman, Philippe Grandjean, Aleksander Giwercman, T. Kold Jensen, M. Skaalum Petersen |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Environmental Pollutants/blood Dichlorodiphenyl Dichloroethylene Denmark Greenland Population Biology Article chemistry.chemical_compound parasitic diseases Spermatozoa/chemistry Humans Polychlorinated Biphenyls/blood education lcsh:Environmental sciences X chromosome General Environmental Science lcsh:GE1-350 Sweden Pollutant Chromosomes Human X education.field_of_study Chromosomes Human Y organic chemicals Chromosome Polychlorinated biphenyl Environmental Exposure Environmental exposure Polychlorinated Biphenyls Spermatozoa Sperm Dichlorodiphenyl Dichloroethylene/blood chemistry 13. Climate action Population study Environmental Pollutants Demography |
| Zdroj: | Kvist, L, Giwercman, A, Weihe, P, Jensen, T K, Grandjean, P, Halling, J, Petersen, M S & Lundberg Giwercman, Y 2014, ' Exposure to persistent organic pollutants and sperm sex chromosome ratio in men from the Faroe Islands ', Environment International, vol. 73, pp. 359-364 . https://doi.org/10.1016/j.envint.2014.09.001 Environment International, Vol 73, Iss, Pp 359-364 (2014) |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2014.09.001 |
| Popis: | People in the Arctic as well as fishermen on the polluted Swedish east coast are highly exposed to persistent organic pollutants (POPs). These compounds have been shown to affect the sperm Y:X chromosome ratio. In present study, the aim was to investigate whether polychlorinated biphenyl (PCB) congeners and 1,1,-dichloro-2,2,-bis(p-chlorophenyl)ethane (p,p′-DDE) influence sperm sex chromosome ratio in Faroese men, and whether these men differ regarding Y:X ratio compared to Greenland Inuit and Swedish fishermen.The study population (n = 449) consisted of young men from the general population (n = 276) as well as proven fertile men (n = 173). The Y:X ratio was assessed by fluorescent in situ hybridization. Serum concentrations of POPs were measured using gas chromatography. Associations between POP concentrations and Y:X ratio were calculated using linear and non-linear regression models as well as trend analysis and pairwise comparison of exposure data categorized into quartiles.The selected POPs were associated with Y:X ratio in fertile Faroese men, but not in the total population; p,p′-DDE (95% CI for B = −0.005 to −0.001, p = 0.005) and ΣPCB (95% CI for B = −0.005 to −0.001, p = 0.012). Since p,p′-DDE and ΣPCB correlated significantly (r = 0.927, p |
| Databáze: | OpenAIRE |
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