Computational Assessment of the Relation Between Embolism Source and Embolus Distribution to the Circle of Willis for Improved Understanding of Stroke Etiology
| Autor: | Neel D. Jani, Kartiga Selvaganesan, Shawn C. Shadden, Debanjan Mukherjee, Christopher L. Weng |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
0206 medical engineering Cerebral arteries Biomedical Engineering Hemodynamics Blood Pressure 02 engineering and technology 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Embolus Physiology (medical) Internal medicine medicine.artery medicine Humans Computer Simulation cardiovascular diseases Stroke Aorta Intracranial Embolism business.industry Models Cardiovascular medicine.disease 020601 biomedical engineering Embolism Cerebrovascular Circulation Pulsatile Flow Cardiology Circle of Willis business Blood Flow Velocity |
| Zdroj: | Journal of Biomechanical Engineering. 138 |
| ISSN: | 1528-8951 0148-0731 |
| DOI: | 10.1115/1.4033986 |
| Popis: | Stroke caused by an embolism accounts for about a third of all stroke cases. Understanding the source and cause of the embolism is critical for diagnosis and long-term treatment of such stroke cases. The complex nature of the transport of an embolus within large arteries is a primary hindrance to a clear understanding of embolic stroke etiology. Recent advances in medical image-based computational hemodynamics modeling have rendered increasing utility to such techniques as a probe into the complex flow and transport phenomena in large arteries. In this work, we present a novel, patient-specific, computational framework for understanding embolic stroke etiology, by combining image-based hemodynamics with discrete particle dynamics and a sampling-based analysis. The framework allows us to explore the important question of how embolism source manifests itself in embolus distribution across the various major cerebral arteries. Our investigations illustrate prominent numerical evidence regarding (i) the size/inertia-dependent trends in embolus distribution to the brain; (ii) the relative distribution of cardiogenic versus aortogenic emboli among the anterior, middle, and posterior cerebral arteries; (iii) the left versus right brain preference in cardio-emboli and aortic-emboli transport; and (iv) the source–destination relationship for embolisms affecting the brain. |
| Databáze: | OpenAIRE |
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