TAURINE IN DEVELOPING RAT BRAIN: CHANGES IN BLOOD-BRAIN BARRIER
| Autor: | Sturman Ja |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Aging
medicine.medical_specialty Taurine business.industry medicine.medical_treatment Intraperitoneal injection Brain Rat brain Blood–brain barrier Biochemistry Rats Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Blood-Brain Barrier Internal medicine Anesthesia medicine Animals business |
| Zdroj: | Journal of Neurochemistry. 32:811-816 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1979.tb04564.x |
| Popis: | — The fate of [35S]taurine injected intraperitoneally or intracranially has been compared in rats throughout neonatal development. The amount of [35S]taurine present in the whole rat pup 24 h after intraperitoneal injection increases during development to a maximum 15 days after birth, and declines thereafter, whereas the amount of [35S]taurine reaching the brain 24 h after intraperitoneal injection was greatest in the first 5 days after birth. The amount of [35S]taurine remaining in the brain 24 h after intracranial injection does not vary throughout the period of neonatal development. These results suggest that the ‘blood-brain’ barrier is more accessible to taurine in the first few days after birth than later in neonatal development, and that factors other than simple exchange are involved. |
| Databáze: | OpenAIRE |
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