Lateral and Basal Amygdala Account for Opposite Behavioral Responses during the Long-Term Expression of Fearful Memories
| Autor: | Annamaria Renna, Eugenio Manassero, Luisella Milano, Benedetto Sacchetti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Basal nucleus lcsh:Medicine Optogenetics Biology Stimulus (physiology) Auditory cortex Amygdala Article 03 medical and health sciences 0302 clinical medicine Memory Avoidance learning Avoidance Learning medicine Animals Rats Wistar lcsh:Science Microscopy Confocal Multidisciplinary Behavior Animal Basolateral Nuclear Complex lcsh:R Central Amygdaloid Nucleus Fear Rats 030104 developmental biology medicine.anatomical_structure Acoustic Stimulation Lateral nucleus lcsh:Q Halorhodopsins Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) |
| Popis: | Memories of fearful events can be maintained throughout the lifetime of animals. Here we showed that lesions of the lateral nucleus (LA) performed shortly after training impaired the retention of long-term memories, assessed by the concomitant measurement of two dissociable defensive responses, freezing and avoidance in rats. Strikingly, when LA lesions were performed four weeks after training, rats did not show freezing to a learned threat stimulus, but they were able to direct their responses away from it. Similar results were found when the central nucleus (CeA) was lesioned four weeks after training, whereas lesions of the basal nucleus (BA) suppressed avoidance without affecting freezing. LA and BA receive parallel inputs from the auditory cortex, and optogenetic inhibition of these terminals hampered both freezing and avoidance. We therefore propose that, at variance with the traditional serial flow of information model, long-term fearful memories recruit two parallel circuits in the amygdala, one relying on the LA-to-CeA pathway and the other relying solely on BA, which operate independently and mediate distinct defensive responses. |
| Databáze: | OpenAIRE |
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