Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents
| Autor: | Soon Gu Kwon, Dae Hyun Roh, Ji Hee Yeo, Seo Yeon Yoon, Alvin J. Beitz, Sol Ji Kim, Jang Hern Lee |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Hot Temperature Drug Resistance Pharmaceutical Science Pharmacology Nitroglycerin chemistry.chemical_compound 0302 clinical medicine Chronic Migraine Mice Knockout integumentary system musculoskeletal neural and ocular physiology Peripheral Nervous System Diseases General Medicine Hindlimb Cold Temperature Allodynia Hyperalgesia Organ Specificity Anesthesia Knockout mouse Diterpenes Facial Nerve Diseases medicine.symptom psychological phenomena and processes Migraine Disorders Neurotoxins Resiniferatoxin TRPV1 TRPV Cation Channels Nerve Tissue Proteins Nitric oxide 03 medical and health sciences medicine Animals Nitric Oxide Donors Neurons Afferent business.industry medicine.disease nervous system diseases Mice Inbred C57BL 030104 developmental biology chemistry Migraine Capsaicin Sensory System Agents business 030217 neurology & neurosurgery |
| Zdroj: | Biological and Pharmaceutical Bulletin. 41:172-181 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b17-00589 |
| Popis: | Despite the relatively high prevalence of migraine or headache, the pathophysiological mechanisms triggering headache-associated peripheral hypersensitivities, are unknown. Since nitric oxide (NO) is well known as a causative factor in the pathogenesis of migraine or migraine-associated hypersensitivities, a mouse model has been established using systemic administration of the NO donor, nitroglycerin (NTG). Here we tried to investigate the time course development of facial or hindpaw hypersensitivity after repetitive NTG injection. NTG (10 mg/kg) was administrated to mice every other day for nine days. Two hours post-injection, NTG produced acute mechanical and heat hypersensitivity in the hind paws. By contrast, cold allodynia, but not mechanical hypersensitivity, occurred in the facial region. Moreover, this hindpaws mechanical hypersensitivity and the facial cold allodynia was progressive and long-lasting. We subsequently examined whether the depletion of capsaicin-sensitive primary afferents (CSPAs) with resiniferatoxin (RTX, 0.02 mg/kg) altered these peripheral hypersensitivities in NTG-treated mice. RTX pretreatment did not affect the NTG-induced mechanical allodynia in the hind paws nor the cold allodynia in the facial region, but it did inhibit the development of hind paw heat hyperalgesia. Similarly, NTG injection produced significant hindpaw mechanical allodynia or facial cold allodynia, but not heat hyperalgesia in transient receptor potential type V1 (TRPV1) knockout mice. These findings demonstrate that different peripheral hypersensitivities develop in the face versus hindpaw regions in a mouse model of repetitive NTG-induced migraine, and that these hindpaw mechanical hypersensitivity and facial cold allodynia are not mediated by the activation of CSPAs. |
| Databáze: | OpenAIRE |
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