Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons

Autor: Łukasz Krych, Dennis Sandris Nielsen, Ivan M. Petyaev, Maria Wiese, Nigel H. Kyle, Tatyana Bandaletova, Witold Kot, Natalia E. Chalyk, Marina P. Chernyshova, Victor A. Klochkov, Yuriy K. Bashmakov, Dmitry V. Pristensky
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Bifidobacterium longum
medicine.medical_treatment
Physiology
lcsh:Medicine
Gut flora
DISEASE
SUPPLEMENTATION
chemistry.chemical_compound
Lycopene
ANTIOXIDANTS
MARKERS
Lactobacillus
Medicine
Chocolate
Skin
biology
General Medicine
Middle Aged
Healthy Volunteers
Liver metabolism
medicine.anatomical_structure
PCR
Liver
BACTERIA
Female
HEALTH
Adult
Article Subject
Dark chocolate
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
food
Humans
Obesity
Muscle
Skeletal
Aged
030109 nutrition & dietetics
General Immunology and Microbiology
business.industry
Prebiotic
lcsh:R
Skeletal muscle
CONSUMPTION
biology.organism_classification
PROBIOTICS
food.food
Gastrointestinal Microbiome
030104 developmental biology
Prebiotics
chemistry
LUTEIN
Clinical Study
business
Zdroj: BioMed Research International, Vol 2019 (2019)
Wiese, M, Bashmakov, Y, Chalyk, N, Nielsen, D S, Krych, L, Kot, W, Klochkov, V, Pristensky, D, Bandaletova, T, Chernyshova, M, Kyle, N & Petyaev, I 2019, ' Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons ', BioMed Research International, vol. 2019, 4625279 . https://doi.org/10.1155/2019/4625279
BioMed Research International
ISSN: 2314-6141
2314-6133
Popis: Lycopene rich food and dark chocolate are among the best-documented products with a broad health benefit. This study explored the systemic effect of lycopene and dark chocolate (DC) on gut microbiota, blood, liver metabolism, skeletal muscle tissue oxygenation and skin. 30 volunteers were recruited for this trial, 15 women and 15 men with a mean age of 55 ± 5.7 years and with moderate obesity, 30 < BMI < 35 kg/m2. They were randomized and divided into five equal interventional groups: three received different formulations of lycopene, one of them with a 7 mg daily dose and two with 30 mg; another group was given 10 g of DC with 7 mg lycopene embedded into its matrix, and the last group received 10 g DC. The trial was double-blinded for the three lycopene groups and separately for the 2 DC groups; the trial lasted for 1 month. By the end of the trial there were dose-dependent changes in the gut microbiota profile in all three lycopene groups with an increase of relative abundance of, e.g.,Bifidobacterium adolescentisandBifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of DC resulted in increased relative abundance of, e.g.,Lactobacillusand a reduction of corneocyte exfoliation. This is the first study which reports the prebiotic potential of lycopene and DC.
Databáze: OpenAIRE
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