Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study
| Autor: | Shu Qi Zhang, Wei Ying Zhang, Fan Fan, Ling Juan Zhang, Wen Qin Ye |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Genotype Bone density Gastroenterology Apolipoproteins E Gene Frequency Bone Density Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Orthopedics and Sports Medicine Allele frequency Alleles Aged Original Paper Polymorphism Genetic business.industry Case-control study Odds ratio Middle Aged Confidence interval Endocrinology Case-Control Studies Spinal Fractures Female Surgery Gene polymorphism business |
| Zdroj: | International Orthopaedics. 38:1665-1669 |
| ISSN: | 1432-5195 0341-2695 |
| Popis: | Although many studies have been performed to evaluate whether or not apolipoprotein E gene (APOE) polymorphisms are differentially associated with bone mineral density (BMD) and fractures, the results have been conflicting. This large-scale study was performed to investigate whether a relationship exists between APOE polymorphisms and risk of fracture. A hospital-based case–control study was conducted in 3,000 patients with fractures and 3,000 age- and gender-matched healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms. Patients with fractures had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR) = 2.02, 95 % confidence interval (CI) = 1.30, 3.14; P = 0.002] than healthy controls. When stratifying by fracture type, it was found that patients with vertebral fractures had a significantly higher frequency of APOE E2/E2 genotype (OR = 2.86, 95 % CI = 1.73, 4.73; P |
| Databáze: | OpenAIRE |
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