Perfusion Quantification of Liver Metastases of Colorectal Cancer Treated with Anti-angiogenic-Based Therapy: Assessment of Intra- and Inter-observer Reproducibility of Parameters in Three Regions of Interest Outlining Lesions
| Autor: | Julie Léger, Aurore Bleuzen, Paul-Armand Dujardin, Thierry Lecomte, Frédéric Patat, Guillaume Chassagnon |
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| Přispěvatelé: | Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), Université de Tours |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Acoustics and Ultrasonics Inter observer reproducibility Colorectal cancer [SDV]Life Sciences [q-bio] Biophysics Angiogenesis Inhibitors 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Therapy assessment Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Aged Ultrasonography Observer Variation Reproducibility Radiological and Ultrasound Technology business.industry Liver Neoplasms Ultrasound Reproducibility of Results Middle Aged medicine.disease Intensity (physics) Regional Blood Flow 030220 oncology & carcinogenesis Female medicine.symptom Colorectal Neoplasms Nuclear medicine business Perfusion |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, Elsevier, 2020, 46, pp.286-296. ⟨10.1016/j.ultrasmedbio.2019.10.011⟩ |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2019.10.011⟩ |
| Popis: | This study evaluated the reproducibility of dynamic contrast-enhanced ultrasound (DCEUS) parameters outlining liver metastases of colorectal cancer in 45 patients, before and after anti-angiogenic-based therapy. Tumor enhancement was quantified by drawing three regions of interest (ROIs): (i) outlining the tumor based on portal phase DCEUS images, (ii) in the hypo-enhanced center of the lesion and (iii) outlining the lesion using parametric imaging. Perfusion parameters were extracted from time-intensity curves. Another ROI was drawn in healthy liver parenchyma for normalization. Intra- and inter-observer reproducibility of these parameters was evaluated using intra-class correlation coefficients (ICCs). For the three ROIs, both intra- and inter-observer reproducibility were excellent (ICCs ≥0.9) for 50.8% absolute parameters and were moderate to good (0.7 ≤ ICC < 0.9) for 26.7% of them. In healthy liver parenchyma and for normalized parameters, reproducibility was moderate to excellent for 59.4% of intensity parameters and was low (ICC |
| Databáze: | OpenAIRE |
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