Reduced white matter integrity in borderline personality disorder: A diffusion tensor imaging study
| Autor: | Haruka Higuma, Fuku Takita, Yoshihisa Kawano, Koji Masuda, Taiga Ninomiya, Jotaro Akiyoshi, Ayako Inoue, Masayuki Kanehisa, Mai Matsuhashi, Chiharu Goto, Harumi Oshita, Toshihiko Izumi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Impulsivity behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Borderline Personality Disorder mental disorders Fasciculus medicine Humans Cingulum (brain) Psychological testing Inferior longitudinal fasciculus Psychiatry Borderline personality disorder biology Depression Beck Depression Inventory Middle Aged biology.organism_classification medicine.disease White Matter 030227 psychiatry Psychiatry and Mental health Clinical Psychology Diffusion Tensor Imaging Case-Control Studies Anxiety Female Nerve Net medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 225:723-732 |
| ISSN: | 0165-0327 |
| Popis: | Background Borderline personality disorder (BPD) has a pervasive pattern of instability in interpersonal relationships, self-image, and emotions. BPD may be linked to an abnormal brain anatomy, but little is known about possible impairments of the white matter microstructure in BPD or their relationship with impulsivity or risky behaviors. The aims of the present study were to explore the relationship between BPD and diffusion tensor imaging (DTI) parameters and psychological tests. Methods We evaluated 35 un-medicated BPD patients in a medication-free state and 50 healthy controls (HCs). We performed DTI tractography in BPD patients and HCs. The Childhood Trauma Questionnaire (CTQ), Profile of Mood State (POMS), State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), Social Adaptation Self-Evaluation Scale (SASS), and Depression and Anxiety Cognition Scale (DACS) were administered to BPD patients and HCs. Results A tract-based spatial statistics (TBSS) revealed that the BPD group had three clusters with a significantly lower axial diffusivity (AD) than the HC group: one located mainly in the cingulum and the other mainly in the inferior front-occipital fasciculus and inferior longitudinal fasciculus. Regarding the AD values, one cluster correlated negatively and significantly with POMS (Depression) and it was located in the cingulum, while another cluster correlated positively and significantly with DACS (Future Denial) and it was located in the inferior front-occipital fasciculus (IFOF). Limitations The small sample size of this study prevents us from forming any definitive conclusions, meaning that more studies are needed to confirm our findings. We are unable to generalize our findings to include other ethnic groups. Conclusions Our results suggested that hypo-metabolism in a front-limbic network dysfunction is characterized by the cingulum and a front-occipital network dysfunction characterized by the occipital lobe, while an occipital-temporal network dysfunction characterized by the inferior longitudinal fasciculus. |
| Databáze: | OpenAIRE |
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