15-year follow-up of a multicenter, randomized, calcineurin inhibitor withdrawal study in kidney transplantation
| Autor: | R. J. Hene, Peter J. H. Smak Gregoor, Luuk B. Hilbrands, Judith A. Kal-van Gestel, Joke I. Roodnat, Arjan D. van Zuilen, Andries J. Hoitsma, Cynthia Konijn, Teun van Gelder, Ruud G. L. de Sévaux, Willem Weimar |
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| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Randomization Time Factors Calcineurin Inhibitors Urology Kaplan-Meier Estimate Drug Administration Schedule law.invention Randomized controlled trial SDG 3 - Good Health and Well-being law Prednisone Risk Factors Multicenter trial medicine Humans Prospective Studies Registries Kidney transplantation Netherlands Proportional Hazards Models Transplantation business.industry Other Research Radboud Institute for Health Sciences [Radboudumc 0] Graft Survival Middle Aged Mycophenolic Acid medicine.disease Kidney Transplantation Surgery Intention to Treat Analysis Calcineurin Regimen Treatment Outcome Creatinine Multivariate Analysis Cyclosporine Female Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] business Biomarkers Immunosuppressive Agents medicine.drug Follow-Up Studies |
| Zdroj: | Transplantation, 98, 47-53 Transplantation, 98(1), 47-53. Lippincott Williams & Wilkins Transplantation, 98, 1, pp. 47-53 |
| ISSN: | 1534-6080 0041-1337 |
| Popis: | Item does not contain fulltext BACKGROUND: Calcineurin inhibitors (CNIs) are essential immunosuppressive drugs after renal transplantation. Because of nephrotoxicity, withdrawal has been a challenge since their introduction. METHODS: A randomized multicenter trial included 212 kidney patients transplanted between 1997 and 1999. All patients were initially treated with mycophenolate mofetil (MMF), cyclosporine A (CsA), and prednisone (pred). At 6 months after transplantation, 63 patients were randomized for MMF/pred, 76 for MMF/CsA, and 73 for MMF/CsA/pred. Within 18 months after randomization 23 patients experienced a rejection episode: MMF/pred (27.0%), MMF/CsA (6.8%) and MMF/CsA/pred (1.4%) (P |
| Databáze: | OpenAIRE |
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