Pharmacokinetics of the venom of Bothrops erythromelas labeled with 131I in mice

Autor:	M.C. Guarnieri, Izabella C. Araujo, R.C. Valença, Maria Bernadete de Souza Maia, Marilene Lopes da Rocha, Demetrius A. M. Araújo
Rok vydání:	2008
Předmět:	biology Ratón education Vascular compartment Ophidia Venom Bothrops erythromelas Pharmacology Toxicology biology.organism_classification complex mixtures Iodine Radioisotopes Mice Pharmacokinetics Crotalid Venoms Injections Intravenous Immunology Blood plasma Animals Bothrops Female
Zdroj:	Toxicon. 52:526-529
ISSN:	0041-0101
DOI:	10.1016/j.toxicon.2008.06.016
Popis:	Bothrops erythromelas venom (BeV) has been responsible for many snake accidents in Brazil. We investigated the plasmatic pharmacokinetic of BeV labeled with 131 I in the absence and the presence of anti- Bothrops serum (BAS). A higher percentage of BeV plasmatic radioactivity and longer elimination were found in the presence of BAS. Our results showed a redistribution of venom from the tissue to vascular compartment associated with the treatment of envenomed mice with anti-venom 15 min after venom injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f058d27f894de7a7959b08f3832cf872 https://doi.org/10.1016/j.toxicon.2008.06.016 Zobrazit plný text záznamu Full Text from ScienceDirect