Metallome evolution in ageingC. elegansand a copper stable isotope perspective
| Autor: | Lucie Sauzéat, Anne Laurençon, Vincent Balter |
|---|---|
| Přispěvatelé: | Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging [SDV]Life Sciences [q-bio] Biophysics chemistry.chemical_element Zinc Calcium Biochemistry Evolution Molecular Biomaterials 03 medical and health sciences 0302 clinical medicine Animals Caenorhabditis elegans chemistry.chemical_classification Reactive oxygen species Stable isotope ratio Metals and Alloys Metallome Copper 030104 developmental biology Copper Radioisotopes chemistry [SDU]Sciences of the Universe [physics] Chemistry (miscellaneous) Ageing Mutation Zinc Isotopes Composition (visual arts) Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Metallomics Metallomics, 2018, 10 (3), pp.496--503. ⟨10.1039/c7mt00318h⟩ Metallomics, Royal Society of Chemistry, 2018, 10 (3), pp.496--503. ⟨10.1039/c7mt00318h⟩ Metallomics, Royal Society of Chemistry, 2018, 10 (3), pp.496-503. ⟨10.1039/C7MT00318H⟩ |
| ISSN: | 1756-591X 1756-5901 |
| DOI: | 10.1039/c7mt00318h |
| Popis: | International audience; Ageing is accompanied by important chemical deregulations resulting in bodily metal imbalances. The way and extent to which these deregulations are associated with ageing processes are however poorly understood and their use as potential biomarkers of ageing has not been investigated. In this study, we report whole-body elementary concentrations and copper and zinc isotopic compositions of Caenorhabditis elegans in ageing wild type (i.e. normal'-lived) and mutant (i.e. short and long-lived) strains. We show that the strains are characterized by different levels of mutation-related variations such as in phosphorus and magnesium as well as in zinc isotopic composition. During ageing, strains are affected by elemental age-related variations, such as an increase in calcium and iron concentrations and a decrease in the copper isotopic composition and concentration for long-lived mutants. The deregulated metabolism of copper seems to be connected to ageing probably in association with the production of reactive oxygen species. We emphasize that the copper stable isotope composition could serve as a biomarker of normal or accelerated ageing in the future. |
| Databáze: | OpenAIRE |
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