Pyrrolizidine alkaloids from Cynoglossum creticum. Synthesis of the pyrrolizidine alkaloids echinatine, rinderine, and analogues
| Autor: | Clarita F. Asibal, Jan A. Glinski, Leon H. Zalkow, Leslie T. Gelbaum |
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| Rok vydání: | 1989 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Pharmaceutical Science Analytical Chemistry Echinatine chemistry.chemical_compound Drug Discovery Organic chemistry Glycosides Pyrrolizidine Alkaloids Pharmacology Cynoglossum creticum biology Bicyclic molecule Molecular Structure Chemistry Alkaloid Organic Chemistry Cholestadienols Galactosides Nuclear magnetic resonance spectroscopy Plants biology.organism_classification Complementary and alternative medicine Pyrrolizidine Molecular Medicine Heliotridine |
| Zdroj: | Journal of natural products. 52(1) |
| ISSN: | 0163-3864 |
| Popis: | Reinvestigation of Cynoglossum creticum led to the isolation of the previously reported echinatine [1] and heliosupine [2] as well as rinderine [3], 7-angelylheliotridine [4] and a new alkaloid, cynoglossamine [5]. The structures have been determined by spectral means (ir, ms, 1H-13C HETCOR nmr), comparison with literature data and authentic samples, and/or syntheses. In addition, 1 and all three of its isomers 3, 6, and 7 and other semisynthetic analogues (8-13) were prepared and characterized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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