Recovery of β-receptors and adenylate cyclase from desensitization induced by short term heat exposure in rat parotid glands
| Autor: | Takayuki Nakamura, Tsuboi Minoru, Tetsuya Izawa, Kazuhiro Suda, Takao Komabayashi, Hiroyuki Fujinami |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Hot Temperature Epinephrine G protein medicine.medical_treatment Cell Magnesium Chloride Down-Regulation Adenylate kinase In Vitro Techniques Biology Guanosine Diphosphate Cyclase Norepinephrine Body Water GTP-Binding Proteins Internal medicine Isoprenaline Receptors Adrenergic beta medicine Animals Parotid Gland Rats Wistar Receptor Desensitization (medicine) Pharmacology Membranes Colforsin Isoproterenol Rats Parotid gland medicine.anatomical_structure Endocrinology Adenylyl Cyclase Inhibitors Adenylyl Cyclases medicine.drug |
| Zdroj: | General Pharmacology: The Vascular System. 24:205-210 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(93)90036-w |
| Popis: | 1. 1. The recovery of rat parotid β-adrenergic receptors (β-AR) and adenylate cyclase (AC) from heat (33°C)-induced desensitization was studied. 2. 2. Down-regulated cell surface β-AR and AC activity in response to isoprenaline (IPR) returned to the control level 120 hr after the termination of heat exposure. 3. 3. However, β-AR in parotid crude membranes increased over the control level for 48–120 hr. 4. 4. Coupling between β-AR and G protein(s) was attenuated at 120 hr. 5. 5. These data suggest that β-AR on the cell surface, but not those internalized, can transduce biological responses. |
| Databáze: | OpenAIRE |
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