A minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells
| Autor: | Franck Raynaud, Mark E. Ambühl, Alicia Bornert, Chiara Gabella, Jean-Jacques Meister, Ivo F. Sbalzarini, Alexander B. Verkhovsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stochastic modelling FOS: Physical sciences General Physics and Astronomy Model system Condensed Matter - Soft Condensed Matter Quantitative Biology::Cell Behavior Minimal model 03 medical and health sciences Optics Cell Behavior (q-bio.CB) Cell polarity Physics - Biological Physics Cell shape Physics business.industry Polarization (waves) Spontaneous polarization 030104 developmental biology Classical mechanics Biological Physics (physics.bio-ph) FOS: Biological sciences Soft Condensed Matter (cond-mat.soft) Mode switching Quantitative Biology - Cell Behavior business |
| Zdroj: | Nature Physics |
| Popis: | How the cells break symmetry and organize their edge activity to move directionally is a fun- damental question in cell biology. Physical models of cell motility commonly rely on gradients of regulatory factors and/or feedback from the motion itself to describe polarization of edge activity. Theses approaches, however, fail to explain cell behavior prior to the onset of polarization. Our analysis using the model system of polarizing and moving fish epidermal keratocytes suggests a novel and simple principle of self-organization of cell activity in which local cell-edge dynamics depends on the distance from the cell center, but not on the orientation with respect to the front-back axis. We validate this principle with a stochastic model that faithfully reproduces a range of cell-migration behaviors. Our findings indicate that spontaneous polarization, persistent motion, and cell shape are emergent properties of the local cell-edge dynamics controlled by the distance from the cell center. 8 pages, 5 figures |
| Databáze: | OpenAIRE |
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