Nitric Oxide-Dependent LTD at Infralimbic Cortex
| Autor: | David Fernández de Sevilla, José Antonio Noriega-Prieto, Yasir Gallero-Salas, Laura Eva Maglio |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Postsynaptic Current Infralimbic cortex Nitric Oxide Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine BAPTA Cortex (anatomy) medicine Animals Prefrontal cortex Neuronal Plasticity Chemistry General Neuroscience Long-Term Synaptic Depression Pyramidal Cells Glutamate receptor Excitatory Postsynaptic Potentials Dendrites Electric Stimulation 030104 developmental biology medicine.anatomical_structure Synaptic plasticity Synapses Excitatory postsynaptic potential Calcium Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience. 418 |
| ISSN: | 1873-7544 |
| Popis: | Dendritic calcium (Ca2+) spikes play a key role in the genesis of long-term synaptic plasticity. Although synaptic plasticity in the infralimbic cortex is critical for the extinction of fear-conditioned memory, the role of Ca2+-spikes in the induction of synaptic plasticity at this cortex has not been explored in depth. Here we show that Ca2+-spikes in layer 5 pyramidal neurons (L5 PNs) of the rat infralimbic cortex are crucial in the induction of long-term depression of the excitatory postsynaptic currents (EPSCs). The lack of effect on the postsynaptic currents evoked by puffing glutamate and the changes in the variance of the EPSC amplitude that paralleled its inhibition suggest that this LTD of the EPSCs is mediated presynaptically. However, its induction requires cytosolic calcium elevations because it is prevented when the recorded L5 PN is loaded with BAPTA. Moreover, it depends on the synthesis of nitric oxide (NO) because it is absent on slices incubated with nitric oxidase synthase inhibitor L-NAME. Therefore, Ca2+-spikes can trigger LTD of the ESPCs through the NO dependent presynaptic form of synaptic plasticity, thus providing a novel form of inducing synaptic plasticity at L5 PNs of the rat infralimbic cortex. |
| Databáze: | OpenAIRE |
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