Predictive value of respiratory symptoms for the diagnosis of pollen-induced seasonal asthma among children and adults in Inner Mongolia
Autor: | Yan Zhuang, Huan Zhong Shi, Ting Ting Ma, Hai Ying Gong, Anthony Yii, Xue Yan Wang |
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Rok vydání: | 2017 |
Předmět: |
Spirometry
Pediatrics medicine.medical_specialty Context (language use) Chest pain Pulmonary function testing 03 medical and health sciences 0302 clinical medicine cough shortness of breath Epidemiology medicine Outpatient clinic Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Respiratory system Original Research Asthma Chemical Health and Safety medicine.diagnostic_test wheezing business.industry General Medicine medicine.disease respiratory tract diseases 030228 respiratory system pollen-induced asthma medicine.symptom asthma symptoms business Safety Research |
Zdroj: | Therapeutics and Clinical Risk Management |
ISSN: | 1178-203X |
Popis: | Background The diagnosis of asthma is made on the basis of variable respiratory symptoms and supported by objective evidence of variable airflow limitation. However, spirometry and bronchoprovocation tests may not be routinely available in resource-scarce settings or in the context of large-scale epidemiological studies. There is a gap in knowledge about the predictive value of respiratory symptoms for the diagnosis of pollen-induced asthma. Objective The aim of this study was to investigate the predictive value of self-reported respiratory symptoms for diagnosing pollen-induced asthma. Patients and methods We recruited 1,161 patients with respiratory symptoms who presented to the respiratory medicine outpatient clinic of two central hospitals in Inner Mongolia during the pollen season of July-September 2015. All patients were interviewed by a respiratory physician and completed a questionnaire survey, lung function tests and skin prick tests for common inhaled allergens. Results A total of 392 patients (33.8%) were diagnosed with asthma and 292 (25.2%, 160 adults, 132 children) with pollen-induced asthma. Respiratory symptoms of cough, wheezing, dyspnea, chest pain and nocturnal awakenings due to breathlessness were all associated with increased odds of being diagnosed with pollen-induced asthma, with cough being the most common symptom in both adults and children, giving a sensitivity of 90.6% in adults and 88.6% in children. Wheezing was the most specific symptom (78% and 89.5% in adults and children, respectively) compared to other symptoms. Overall, the positive predictive value of respiratory symptoms was poor for diagnosing pollen-induced asthma, with the exception of wheezing in children which had a high positive predictive value of 72.7%. Conclusion Cough was the predominant symptom in adults and children with pollen-induced asthma. Wheezing was a reliable predictor of pollen-induced asthma in children. In adults, respiratory symptoms were not sufficiently reliable for diagnosing pollen-induced asthma. |
Databáze: | OpenAIRE |
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