Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model
| Autor: | Vitor M. Correlo, Raphaël F. Canadas, Laura Freitas, Andres E. Carrillo, Parakevi Gkiata, Maria Vliora, Tânia Amorim, Franklim Marques, Georgia Ntina, Ana R. N. Bastos, Rui Pinto, Henrique Reguengo, Bruno M. Fonseca, Yiannis Koutedakis, Rui L. Reis, Joaquim M. Oliveira, Eirini K. Kydonaki, Carlos Simón, Emanuel M. Fernandes |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Předmět: |
Supplementation
Osteoporosis bone Bone remodeling 0302 clinical medicine Bone Density TX341-641 0303 health sciences Nutrition and Dietetics biology medicine.anatomical_structure RANKL Ovariectomized rat Female Bovine colostrum Ciências Agrárias::Biotecnologia Agrária e Alimentar medicine.medical_specialty Biotecnologia Agrária e Alimentar [Ciências Agrárias] Ovariectomy 030209 endocrinology & metabolism Placebo Bone resorption Bone and Bones Article 03 medical and health sciences Internal medicine medicine Animals Rats Wistar Bone 030304 developmental biology Science & Technology business.industry Nutrition. Foods and food supply Colostrum medicine.disease osteoporosis Rats bovine colostrum Disease Models Animal Endocrinology Dietary Supplements supplementation biology.protein Cortical bone Cattle business Food Science |
| Zdroj: | Nutrients Volume 13 Issue 9 Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Nutrients, Vol 13, Iss 2981, p 2981 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13092981 |
| Popis: | Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidectomized (ORX) rat models. Twenty-seven-week-old Wistar Han rats were randomly assigned as: (1) placebo control, (2) BC supplementation dose 1 (BC1: 0.5 g/day/OVX, 1 g/day/ORX), (3) BC supplementation dose 2 (BC2: 1 g/day/OVX, 1.5 g/day/ORX) and (4) BC supplementation dose 3 (BC3: 1.5 g/day/OVX, 2 g/day/ORX). Bone microarchitecture, strength, gene expression of VEGFA, FGF2, RANKL, RANK and OPG, and bone resorption/formation markers were assessed after four months of BC supplementation. Compared to the placebo, OVX rats in the BC1 group exhibited significantly higher cortical bone mineral content and trabecular bone mineral content (p < 0.01), while OVX rats in the BC3 group showed significantly higher trabecular bone mineral content (p < 0.05). ORX rats receiving BC dose 2 demonstrated significantly higher levels of trabecular bone mineral content (p < 0.05). Serum osteocalcin in the ORX was pointedly higher in all BC supplementation groups than the placebo (BC1: p < 0.05 BC2, BC3: p < 0.001). Higher doses of BC induced significantly higher relative mRNA expression of OPG, VEGFA, FGF2 and RANKL (p < 0.05). BC supplementation improves bone metabolism of OVX and ORX rats, which might be associated with the activation of the VEGFA, FGF2 and RANKL/RANK/OPG pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|