Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
| Autor: | Shixi Liu, Jia Ren, Jun Liu, Hui Yang, Qiao Wen, Jian Zou, Juanjuan Hu, Jing Zhou, Dan Lu, Weigang Gan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Larynx
Adult Male medicine.medical_specialty medicine.medical_treatment lcsh:Surgery Laryngectomy Case Report Hemilaryngectomy Lesion 03 medical and health sciences 0302 clinical medicine Rhabdomyosarcoma medicine Humans Rhabdomyosarcoma Embryonal Diagnostic Errors Anticancer drug sensitivity Laryngeal Neoplasms Chemotherapy business.industry Laryngeal rhabdomyosarcomas lcsh:RD1-811 General Medicine Chemoradiotherapy medicine.disease Combined Modality Therapy Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Neck Dissection 030211 gastroenterology & hepatology Female Embryonal rhabdomyosarcoma Multidiscipline medicine.symptom Neoplasm Recurrence Local business Chemosensitivity assay |
| Zdroj: | BMC Surgery BMC Surgery, Vol 20, Iss 1, Pp 1-7 (2020) |
| ISSN: | 1471-2482 |
| Popis: | Background Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. Case presentation A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases. Conclusions Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink