Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy—A randomized controlled trial

Autor: Fabrício Gomes da Silva, Márcia Helena Miranda Cardoso Podestá, Thayná Coelho Silva, Carlos Marcelo de Barros, Breno Fialho Vitarelli de Carvalho, Tiago Marques dos Reis, Milena Carla Espósito, Danielle Aparecida Ferreira de Oliveira Marrafon, Denismar Alves Nogueira, Sudhir Diwan, Carla Speroni Ceron, Larissa Helena Torres
Rok vydání: 2022
Předmět:
Zdroj: Clinical and Experimental Pharmacology and Physiology. 50:256-263
ISSN: 1440-1681
0305-1870
DOI: 10.1111/1440-1681.13742
Popis: Postoperative pain is one of the main negative symptoms resulting from surgery and the use of new methods to control this symptom is of ever-increasing relevance. Opioid-sparing strategies, such as multimodal analgesia, are trends in this scenario. Pregabalin is a well-established treatment for neuropathic pain; however, it is still controversial in the surgical context for postoperative analgesia. The aim of this study was to investigate the effect of pregabalin on postoperative analgesia in patients undergoing abdominal hysterectomy.A prospective, randomized, double-blind, placebo-controlled clinical trial. Female patients undergoing abdominal hysterectomy were randomized to use pregabalin (group P1), 300 mg orally 2 hours before surgery, or identical placebo pills (group P0). The main outcome includes the postoperative pain index by visual analog scale (VAS) and McGill's pain questionnaire. Secondary outcomes include opioid consumption and the presence of adverse effects. A value of p 0.05 was used to reject type I error.Fifty-five patients were randomized among the groups. Patients in group P1 had lower pain rates by VAS scale, both at rest and in active motion, than group P0. In McGill's questionnaire, patients from group P1 also had lower pain rates (12 x 28.5). There was approximately twice as much opioid consumption among patients in group P0. Regarding side effects, there was a difference between the two groups only for dizziness, being more incident in group P1.This study suggests that pregabalin is an important adjuvant drug in treating postoperative pain in patients with abdominal hysterectomy. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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