Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019
| Autor: | Dania Al Ismail, Alessandra Oliva, Claudio Maria Mastroianni, Lorenzo Loffredo, Raissa Aronica, F. Cancelli, Vera Mauro, Maria Claudia Miele, Massimiliano De Angelis, Federica Di Timoteo, Emanuele Rando |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
endothelial activation Disease Logistic regression Article law.invention Endothelial activation law Internal medicine E-selectin medicine biology business.industry SARS-CoV-2 COVID-19 General Medicine medicine.disease Thrombosis Intensive care unit Absolute neutrophil count biology.protein Biomarker (medicine) Medicine covid-19 e-selectin sars-cov-2 business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 4018, p 4018 (2021) Journal of Clinical Medicine Volume 10 Issue 17 |
| ISSN: | 2077-0383 |
| Popis: | Introduction: E-selectin is a recognized marker of endothelial activation however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-admitted and non-admitted, survived and non-survived patients and those with or without thrombosis. Methods: A single-center study of patients with COVID-19 hospitalized at Policlinico Umberto I (Rome) from March to May 2020 was performed. Simple and multiple logistic regression models were developed. Results: One hundred patients were included, with a median age (IQR) of 65 years (58–78). Twenty-nine (29%) were admitted to ICU, twenty-eight (28%) died and nineteen (19%) had a thrombotic event. The median value (IQR) of sE-selectin was 26.1 ng/mL (18.1–35). sE-selectin values did not differ between deceased and survivors (p = 0.06) and among patients with or without a thrombotic event (p = 0.22). Compared with patients who did not receive ICU treatments, patients requiring ICU care had higher levels of sE-selectin (36.6 vs. 24.1 ng/mL p < 0.001). In the multiple logistic regression model, sE-selectin levels > 33 ng/mL, PaO2/FiO2 < 200 and PaO2/FiO2 200–300 were significantly associated with an increased risk of ICU admission. sE-selectin values significantly correlated with a neutrophil count (R = 0.32 (p = 0.001)) and the number of days from the symptoms onset to hospitalization (R = 0.28 (p = 0.004)). Conclusions: sE-selectin levels are predictive of ICU admission in COVID-19 patients. Since data on the relation between sE-selectin and COVID-19 are scarce, this study aims to contribute toward the comprehension of the pathogenic aspects of COVID-19 disease, giving a possible clinical marker able to predict its severity. |
| Databáze: | OpenAIRE |
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