In vitro anthelmintic activity and chemical composition of methanol extracts and fractions of Croton paraguayensis and Vernonia brasiliana against Eisenia fetida
| Autor: | María Cristina Romero-Rodríguez, María Eugenia Flores-Giubi, Nelson Alvarenga, Andrea Leticia Cáceres |
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| Rok vydání: | 2017 |
| Předmět: |
Croton paraguayensis
Microbiology (medical) Eisenia fetida lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 030231 tropical medicine lcsh:Medicine 01 natural sciences Vernonia brasiliana 03 medical and health sciences chemistry.chemical_compound Alkaloids 0302 clinical medicine Botany Anthelmintic medicine Chemical composition biology Chemistry lcsh:R 010401 analytical chemistry biology.organism_classification Croton In vitro 0104 chemical sciences Infectious Diseases Methanol medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 7, Iss 2, Pp 71-74 (2017) |
| ISSN: | 2222-1808 |
| DOI: | 10.12980/apjtd.7.2017d6-381 |
| Popis: | Objective: To evaluate the chemical composition and the anthelmintic activity of the methanol extracts and the acid and basic fractions of Croton paraguayensis (C. paraguayensis) and Vernonia brasiliana (V. brasiliana) against Eisenia fetida. Methods: A preliminary phytochemical analysis was performed to assess the presence of groups of secondary metabolites. The plants were extracted with methanol to obtain the crude extracts. A differential pH extraction was performed to isolate basic compounds like alkaloids. The methanolic extracts and the fractions obtained were tested for anthelmintic activity against Eisenia fetida, using albendazole as positive control. Results: The phytochemical test demonstrated the presence of alkaloids in the crude extracts and alkaline fractions, along with flavonoids, coumarins, steroids/triterpenes and tannins. The anthelmintic activity of the extracts and fractions of C. paraguayensis and V. brasiliana showed a statistically significant decrease of the times for paralysis and death compared to albendazole. Conclusions: The methanolic extracts and fractions of C. paraguayensis and V. brasiliana contain compounds that possess anthelmintic activity. The isolation of the substances responsible for the biological effect described could result in the development of new drugs to treat helminth diseases. |
| Databáze: | OpenAIRE |
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