A Kelch domain-containing KLHDC7B and a long non-coding RNA ST8SIA6-AS1 act oppositely on breast cancer cell proliferation via the interferon signaling pathway

Autor:	Sungbin Park, Hansol Bae, Han-Sung Kang, Gookjoo Jeong, Hyeon Woo Kim, Juyeon Ham, Sun Jung Kim, Dawoon Jeong
Rok vydání:	2018
Předmět:	0301 basic medicine Therapeutic gene modulation lcsh:Medicine Breast Neoplasms Biology medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Breast cancer Downregulation and upregulation Cell Movement Interferon Cell Line Tumor medicine Humans lcsh:Science Adaptor Proteins Signal Transducing Cell Proliferation Regulation of gene expression Multidisciplinary Reverse Transcriptase Polymerase Chain Reaction Interleukins lcsh:R RNA-Binding Proteins Flow Cytometry medicine.disease Gene Expression Regulation Neoplastic STAT Transcription Factors 030104 developmental biology Apoptosis 030220 oncology & carcinogenesis MCF-7 Cells Cancer research RNA Long Noncoding lcsh:Q Interferons Signal transduction Carrier Proteins Carcinogenesis Signal Transduction medicine.drug
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-018-31306-8
Popis:	In our previous study, the Kelch domain-containing 7B (KLHDC7B) was revealed to be hypermethylated at the promoter but upregulated in breast cancer. In this study, we identified a long non-coding RNA, ST8SIA6-AS1 (STAR1), whose expression was significantly associated with KLHDC7B in breast cancer (R2 = 0.3466, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04d48a25f49155f3cb52c9e3d50c467 https://doi.org/10.1038/s41598-018-31306-8 Zobrazit plný text záznamu